Cimzia® - Axial spondyloarthritis (axSpA)

In Europe, Cimzia® (certolizumab pegol)  is indicated for the treatment of adult patients with severe active axial spondyloarthritis, comprising:
Adults with severe active ankylosing spondylitis who have had an inadequate response to, or are intolerant to nonsteroidal anti-inflammatory drugs (NSAIDs).

Axial spondyloarthritis without radiographic evidence of AS
Adults with severe active axial spondyloarthritis without radiographic evidence of AS but with objective signs of inflammation by elevated CRP and /or MRI, who have had an inadequate response to, or are intolerant to NSAIDs.