Pipeline | UCB
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PIPELINE

 

Our researchers, assisted by world class facilities and ground-breaking scientific platforms, are continually evolving and improving our science, their knowledge and capabilities. This has fueled a strong pipeline spanning several therapy areas that we are confident will deliver highly differentiated solutions.

 

Molecule
Modality
Therapeutic Area
Indication
Phase
1 2 3 Filing
Information
Bimekizumab
Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Immunology
Psoriasis
Filing in the USA. Approved in EU, GB, Japan, Canada
Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Immunology
Psoriatic arthritis
Submission Q3 2022
Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Immunology
Axial spondyloarthritis
Submission Q3 2022
Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Immunology
Hidradenitis suppurativa
Topline results H2 2022
Monoclonal antibody

Bimekizumab is an investigational humanized monoclonal IgG antibody that selectively inhibits both IL-17A and IL-17F, two key cytokines driving inflammatory processes.

Zilucoplan
Macrocyclic peptide

Zilucoplan is an investigational macrocyclic peptide inhibitor of complement component 5 (C5). The U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to zilucoplan for the treatment of myasthenia gravis.

Neurology
Generalized myasthenia gravis
Submission Q3 2022
Macrocyclic peptide

Zilucoplan is an investigational macrocyclic peptide inhibitor of complement component 5 (C5). The U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to zilucoplan for the treatment of myasthenia gravis.

Rozanolixizumab
Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Neurology
Generalized myasthenia gravis
Submission Q3 2022
Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Immunology
Immune thrombocytopenia
Topline results H2 2022
Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Neurology
Myelin oligodendrocyte glycoprotein (MOG) antibody disease
Topline results H2 2024
Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Neurology
Autoimmune encephalitis
Topline results H1 2024
Monoclonal antibody

Rozanolixizumab is an investigational humanized monoclonal antibody that specifically binds to human neonatal Fc receptor (FcRn). It has been designed to block the interaction of FcRn and IgG, inhibiting IgG recycling and inducing the removal of pathogenic IgG autoantibodies.

Dapirolizumab pegol
Monoclonal antibody

Dapirolizumab pegol is an investigational humanised monovalent pegylated Fab antibody fragment against the CD40 ligand (CD40L). Through interactions with its receptor, CD40, CD40L plays an important role in regulating interactions between T cells and other immune cells and thus affects several important functional events thought to be involved in autoimmune disease.

Dapirolizumab pegol is being co-developed with Biogen.

Immunology
Systemic lupus erythematosus
Topline results H1 2024
Monoclonal antibody

Dapirolizumab pegol is an investigational humanised monovalent pegylated Fab antibody fragment against the CD40 ligand (CD40L). Through interactions with its receptor, CD40, CD40L plays an important role in regulating interactions between T cells and other immune cells and thus affects several important functional events thought to be involved in autoimmune disease.

Dapirolizumab pegol is being co-developed with Biogen.

Staccato® (alprazolam)
Small molecule

STACCATO® alprazolam is an investigational drug-device combination using STACCATO® delivery technology with alprazolam, a benzodiazepine, that has the potential to be the first rescue treatment to be administered by a patient or caregiver in an out-patient setting to rapidly terminate (within 90 seconds) an ongoing seizure.

Neurology
Stereotypical prolonged seizures
Topline results H1 2024
Small molecule

STACCATO® alprazolam is an investigational drug-device combination using STACCATO® delivery technology with alprazolam, a benzodiazepine, that has the potential to be the first rescue treatment to be administered by a patient or caregiver in an out-patient setting to rapidly terminate (within 90 seconds) an ongoing seizure.

Bepranemab
Monoclonal antibody

Bepranemab is an investigational recombinant, humanised, full length IgG4 monoclonal anti-tau antibody with specificity for human tau protein.

Bepranemab is being co-developed with Roche/Genentech

Neurology
Alzheimer's disease
Topline results H1 2025
Monoclonal antibody

Bepranemab is an investigational recombinant, humanised, full length IgG4 monoclonal anti-tau antibody with specificity for human tau protein.

Bepranemab is being co-developed with Roche/Genentech

UCB0599
Small molecule

UCB0599 is an investigational small molecule that prevents the pathological misfolding and accumulation of alpha-synuclein, a protein which plays a role in Parkinson’s disease (PD) pathology. Inhibition of alpha-synuclein misfolding has the potential to slow down the progression of PD.

UCB0599 belongs to a series of molecules discovered by Neuropore, which were in-licensed by UCB in 2014.

UCB0599 is being co-developed with Novartis.

Neurology
Parkinson's disease
Topline results H2 2023
Small molecule

UCB0599 is an investigational small molecule that prevents the pathological misfolding and accumulation of alpha-synuclein, a protein which plays a role in Parkinson’s disease (PD) pathology. Inhibition of alpha-synuclein misfolding has the potential to slow down the progression of PD.

UCB0599 belongs to a series of molecules discovered by Neuropore, which were in-licensed by UCB in 2014.

UCB0599 is being co-developed with Novartis.