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Our Science Glossary glossary_h

Glossary

H1-receptor

In common use, the term antihistamine refers only to H1-receptor antagonists, also known as H1-antihistamines. See also antihistamine, histamine.

High throughput screening or HTS

A method used for scientific experimentation especially relevant to the fields of biology and chemistry. Through a combination of modern robotics and other specialised laboratory hardware using automated assays, it allows a researcher effectively to conduct hundreds of scientific experiments at once to search through large numbers of substances for desired activity, resulting in a less costly and faster approach to finding new drugs.

Histamine

A chemical released during allergic reactions responsible for many of the symptoms associated with allergic reactions. Its release stimulates many smooth muscles to contract, such as those in the gastrointestinal tract, uterus, and the bronchi. It also causes fine blood vessels to dilate and become more permeable, which causes the common allergy symptoms of runny nose, watery eyes, and tissue swelling.

Hyper-excitability

Increased activity and restlessness.

Hypersynchronisation

The excitation of whole groups of neurons which can lead to an epileptic event (seizure). Neurons are electrically excitable cells in the CNS that process and transmit information. In vertebrate animals, neurons are the core components of the brain, spinal cord and peripheral nerves.