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Briviact®️ (brivaracetam)
| Disease area studied |
Abbreviated title | Phase | Study ID | Registry database | Study results | Lay summary | Publication (if available) |
|---|---|---|---|---|---|---|---|
| Epilepsy | A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Intravenous Brivaracetam in Subjects >= 1 Month to < 16 Years of Age With Epilepsy |
EP0065 Completed |
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| Epilepsy |
A Study to Evaluate the Efficacy and Safety of Adjunctive Brivaracetam in Asian Subjects (>=16 to 80 Years of Age) With Epilepsy |
EP0083 Ongoing |
NCT03083665 | ||||
| Epilepsy | A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization |
EP0085 Ongoing |
NCT03250377 | ||||
| Epilepsy | A Study to Assess the Efficacy and Safety of Brivaracetam as Treatment for Increased Seizure Activity in an Epilepsy Monitoring Unit Setting |
EP0087 Completed |
NCT03021018 |
|
Szaflarski J.P, et al. Epilepsy Behav 2020; 109:107127 |
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| Epilepsy | A Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam (BRV) as Replacement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization |
EP0118 Ongoing |
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| Epilepsy | Effect of Brivaracetam in Photosensitive Epileptic Subjects |
N01069 Completed |
|
PDF
|
Kasteleijn-Nolst Trenite D.G., et al. Neurology 2007; 69(10):1027–34 |
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| Epilepsy | A Study of Brivaracetam in Subjects With Partial Onset Seizures |
N01114 Completed |
NCT00175929 2004-001856-35 |
LINK |
Van Paesschen et al. Epilepsia;2013;54;1;89-97. | ||
| Epilepsy | Follow-up Trial to Evaluate Long-term Safety and Efficacy of Brivaracetam in Subjects Suffering From Epilepsy |
N01125 Completed |
NCT00175916 2004-002140-10 |
LINK |
Ben-Menachem E., et al. Epilepsy Res 2020 [ePub] | ||
| Tremor | A randomized placebo-controlled, 2-way crossover, multicenter, single-blind study to explore the efficacy of ucb 34714 in a minimum of 40 subjects suffering from mild to moderate essential tremor after 14 days of multiple oral doses up to 400 mg b.i.d., 50 mg or 200 mg capsules |
N01129 Completed |
PDF
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| Epilepsy | Monocenter, open label, unilateral metabolic interaction study of ucb 34714 (100, 200 and 400 mg daily) on carbamazepine (≥ 600 mg daily) during a four-week bid administration period in 9 adult male subjects suffering from epilepsy |
N01133 Completed |
PDF
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| Epilepsy | Multicenter, open label, unilateral metabolic interaction study of ucb 34714 (100, 200 and 400 mg daily) on carbamazepine (>=600 mg daily) during a four-week bid administration period in 9 adult male subjects suffering from epilepsy and treated with carbamazepine and valproate (>=500 mg daily) |
N01135 Completed |
PDF
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| Postherpetic Neuralgia | A Study Assessing Efficacy of Brivaracetam in Subjects With Persistent Pain After Shingles (Post-herpetic Neuralgia) |
N01162 Completed |
NCT00160667 2004-000975-32 |
LINK LINK |
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| Epilepsy | A Monocenter, Open-Label, Unilateral Interaction Study of ucb 34714 (400 mg daily) on Stable Phenytoin Monotherapy During a 45 day b.i.d. Administration Period in 15 Adult Subjects Suffering from Epilepsy |
N01172 Completed |
PDF
|
Moseley B.D. et al. [abstract 2.207] available on Annual Meeting Abstract Database www.aesnet.org | |||
| Unverricht-Lundborg Disease | Brivaracetam as add-on Treatment of Unverricht-Lundborg Disease in Adolescents and Adults |
N01187 Completed |
NCT00357669 2006-000169-12 |
LINK |
Kalviainen, R.,et al Epilepsia;2016; 57;2;210-221 |
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| Epilepsy |
A Dose-ranging Study With Brivaracetam in Patients From 16 to 65 Years With Refractory Partial Onset Seizures. |
N01193 Completed |
NCT00175825 |
LINK |
French et al. Neurology;2010; 75;6;519-525. | ||
| Epilepsy | Open-label Follow up Trial to Evaluate Long-term Safety and Efficacy of Brivaracetam in Subjects Aged 16 Years or Older Suffering From Epilepsy. |
N01199 Completed |
NCT00150800 |
LINK |
O'Brien T.J., Epilepsia 2020; 61(4):636–46 | ||
| Unverricht-Lundborg Disease |
Brivaracetam as add-on Treatment of Unverricht-Lundborg Disease in Adolescents and Adults |
N01236 Completed |
NCT00368251 2006-001536-46 |
LINK LINK |
Kalviainen, R.,et al Epilepsia;2016; 57;2;210-221 |
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| Epilepsy | Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures |
N01252 Completed |
NCT00490035 2006-006344-59 |
LINK LINK |
Ryvlin et al. Epilepsia; 2014;55;1;47-56. | ||
| Epilepsy | Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures |
N01253 Completed |
NCT00464269 2006-006345-14 |
LINK |
Biton et al. Epilepsia; 2014;55;1;57-66. | ||
| Epilepsy | Brivaracetam as add-on Treatment in Adolescents and Adults Suffering From Epilepsy |
N01254 Completed |
NCT00504881 2006-006346-34 |
LINK LINK |
Kwan et al. Epilepsia; 2014;55;1;38-46. | ||
| Epilepsy | Safety and Tolerability of Intravenous Brivaracetam (Infusion or Bolus) as Adjunctive Antiepileptic Therapy |
N01258 Completed |
NCT01405508 2008-004714-27 |
LINK LINK |
Klein et al. Epilepsia;2016; 57;7;1130-1138 |
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| Epilepsy | Open-label, Pharmacokinetic, Safety and Efficacy Study of Adjunctive Brivaracetam in Children With Epilepsy. |
N01263 Completed |
NCT00422422 2006-006536-22 |
|
Liu E. et al. Paediatr Drugs 2019; 21(4):291–301 | ||
| Epilepsy | Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy |
N01266 Ongoing |
NCT01364597 2011-000374-60 |
PDF
|
Badalamenti V. et al. Ann Neurol 2017; 82(Suppl. 21):S278-S279 46th Annual Meeting of the Child Neurology Society (CNS), October 04-07, 2017; Missouri, USA |
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| Epilepsy | A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures |
N01276 Terminated |
NCT00698581 2008-000144-14 |
LINK LINK |
Arnold S., et al. Epilepsy Res 2018; 141:73–82 | ||
| Epilepsy | A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures |
N01306 Terminated |
NCT00699283 2008-000145-58 |
LINK LINK |
Arnold S., et al. Epilepsy Res 2018; 141:73–82 | ||
| Epilepsy | An Open-label, Multinational, Multicenter, Follow-up Study to Evaluate the Long-term Safety and Efficacy of Brivaracetam |
N01315 Completed |
NCT00761774 2008-001433-98 |
LINK |
Arnold S., et al. Epilepsy Res 2020 166:106404 | ||
| Electroencephalographic Neonatal Seizures | A Study to Test the Pharmacokinetics, Efficacy, and Safety of Brivaracetam in Newborns With Repeated Electroencephalographic Seizures |
N01349 Ongoing |
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| Epilepsy | Brivaracetam Efficacy and Safety Study in Subjects With Partial Onset Seizures (BRITE™) |
N01358 Completed |
NCT01261325 2010-019361-28 |
LINK LINK |
Klein, P. et al., Epilepsia; e-pub 10-16-2015; | ||
| Epilepsy | Evaluation of Long-term Safety, and Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects With Epilepsy |
N01372 Completed |
NCT01728077 2012-000827-42 |
LINK LINK |
Borghs S., et al. [abstract 2.287] available on Annual Meeting Abstract Database www.aesnet.org | ||
| Epilepsy | Brivaracetam Safety and Efficacy Follow-up Study in Subjects With Epilepsy (BRITE™) |
N01379 Completed |
NCT01339559 2010-020345-27 |
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| Epilepsy | Efficacy Evaluation of Intravenous Brivaracetam and Phenytoin in Subjects With Nonconvulsive Electrographic Seizures |
N01394 Terminated |
NCT02088957 |
LINK |
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| Epilepsy | Effect of Brivaracetam (BRV) on Nonpsychotic Behavioral Side Effects in Subjects Treated Previously With Levetiracetam (LEV) |
N01395 Completed |
NCT01653262 2011-005177-23 |
LINK LINK |
Yates, S. L. et al. Epilepsy Behav;2015;52;Pt A;165-168 |