Case studies

UCB has an established track record as a partner and has proven its ability to build successful and sustainable relationships.
The following case studies illustrate this success:

Immunomedics

• In May 2006, Immunomedics and UCB announced a collaboration and license agreement for epratuzumab (humanized anti-CD22 monoclonal antibody). The agreement granted UCB the exclusive worldwide rights to develop, market and sell epratuzumab for all autoimmune disease indications.
• In August 2009, UCB and Immunomedics announced positive results for epratuzumab Phase IIb study in systemic lupus erythematosus (SLE).
• In December 2010, UCB announced start of phase III programme with epratuzumab for patients with moderate to severe systemic lupus erythematosus

Pfizer

• UCB and Pfizer long-term collaboration started already in the 1950's when UCB licensed Atarax^® (hydroxyzine) to Pfizer.
• In 1987, UCB and Pfizer signed a licensing agreement for Zyrtec^® (cetirizine) for the US territory. Both companies have been successfully co-promoting Zyrtec^® in the US since 1996 and the product reached blockbuster status.
• A discovery and development collaboration of antibody-based drugs Mylotarg^® (gemtuzumab ozogamicin for injection), a pioneering treatment for Acute Myeloid Leukaemia (AML) marketed in the US and Japan, and CMC-544 an IgG4 antibody which delivers calicheamicin to CD22 positive cells, currently being evaluated in Phase III trials in patients with Non-Hodgkins lymphoma.
• Toviaz^® (fesoterodine) for the treatment of overactive bladder is also licensed to Pfizer.
  

Wilex

• In January 2009, UCB and Wilex entered into a strategic alliance to develop UCB's preclinical oncology portfolio composed of five programmes. The joint development strategy includes buyback options for UCB and UCB becomes a strategic investor in Wilex.